Source:http://linkedlifedata.com/resource/pubmed/id/19079226
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2008-12-16
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| pubmed:abstractText |
There is evidence that Foxp3(+) regulatory T (T(R)) cells contribute to intestinal homeostasis and that deficiencies in this population can lead to chronic intestinal inflammation. Here, we review recent studies that demonstrate that the gut is a site of peripheral generation of T(R) cells. Functionally specialized gut dendritic cell populations promote T(R) cells through a transforming growth factor-beta and retinoic acid-dependent mechanism. Gut-driven T(R) cells may represent a tissue-specific mechanism to broaden the repertoire of T(R) cells focussed on the gut.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1935-3456
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
1 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S34-8
|
| pubmed:meshHeading |
pubmed-meshheading:19079226-Animals,
pubmed-meshheading:19079226-Antigens, CD,
pubmed-meshheading:19079226-Dendritic Cells,
pubmed-meshheading:19079226-Forkhead Transcription Factors,
pubmed-meshheading:19079226-Humans,
pubmed-meshheading:19079226-Integrin alpha Chains,
pubmed-meshheading:19079226-Intestines,
pubmed-meshheading:19079226-Lymphoid Tissue,
pubmed-meshheading:19079226-T-Lymphocytes, Regulatory
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
CD103+ GALT DCs promote Foxp3+ regulatory T cells.
|
| pubmed:affiliation |
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
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| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|