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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-20
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pubmed:abstractText |
Immune-related mechanisms are involved in various neurological diseases and although mesenchymal stem cells (MSCs) have been shown to repair and replace injured neurons, it remains uncertain what the immune cells in the brain do during this process. Microglial cells are the representatives of immune cells in the brain. Microglial cells, injured neurons and stem cells often coexist in the same microenvironment. To investigate the effect of microglial cells on stem cells in such an environment, we tried to see how microglial cells affect the neurotrophicity of MSCs after being stimulated with injured neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1423-0216
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-34
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pubmed:meshHeading |
pubmed-meshheading:19077443-Animals,
pubmed-meshheading:19077443-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:19077443-Cell Communication,
pubmed-meshheading:19077443-Coculture Techniques,
pubmed-meshheading:19077443-Culture Media, Conditioned,
pubmed-meshheading:19077443-Encephalitis,
pubmed-meshheading:19077443-Fibroblast Growth Factor 2,
pubmed-meshheading:19077443-Mesenchymal Stem Cells,
pubmed-meshheading:19077443-Microglia,
pubmed-meshheading:19077443-Nerve Growth Factor,
pubmed-meshheading:19077443-Nerve Growth Factors,
pubmed-meshheading:19077443-Nerve Regeneration,
pubmed-meshheading:19077443-Neurons,
pubmed-meshheading:19077443-PC12 Cells,
pubmed-meshheading:19077443-Rats,
pubmed-meshheading:19077443-Rats, Sprague-Dawley,
pubmed-meshheading:19077443-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
BV2 enhanced the neurotrophic functions of mesenchymal stem cells after being stimulated with injured PC12.
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pubmed:affiliation |
Department of Neurology, First Affiliated Hospital, China Medical University.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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