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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-2-4
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pubmed:abstractText |
The scaffold attachment factor B1 and B2 genes, SAFB1/SAFB2 (both located on chromosome 19p13.3) have recently been suggested as tumour suppressor genes involved in breast cancer development. The assumption was based on functional properties of the two genes and loss of heterozygosity of intragenic markers in breast tumours further strengthened the postulated hypothesis. In addition, linkage studies in Swedish breast cancer families also indicate the presence of a susceptibility gene for breast cancer at the 19p locus. Somatic mutations in SAFB1/SAFB2 have been detected in breast tumours, but to our knowledge no studies on germline mutations have been reported. In this study we investigated the possible involvement of SAFB1/SAFB2 on familiar breast cancer by inherited mutations in either of the two genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-10707955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-10852375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-11207044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-12660241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-14560309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-14587024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-15755967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-16195251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-16575876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-17171685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-17293864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-17437280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-17529967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-17760956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-1933872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-1997094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-8364930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-9428765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-9490290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19077293-9832031
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
108
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19077293-Breast Neoplasms,
pubmed-meshheading:19077293-Chromosomes, Human, Pair 19,
pubmed-meshheading:19077293-Female,
pubmed-meshheading:19077293-Genes, BRCA1,
pubmed-meshheading:19077293-Genes, BRCA2,
pubmed-meshheading:19077293-Genetic Linkage,
pubmed-meshheading:19077293-Germ-Line Mutation,
pubmed-meshheading:19077293-Humans,
pubmed-meshheading:19077293-Matrix Attachment Region Binding Proteins,
pubmed-meshheading:19077293-Nuclear Matrix-Associated Proteins,
pubmed-meshheading:19077293-Nucleic Acid Amplification Techniques,
pubmed-meshheading:19077293-Polymerase Chain Reaction,
pubmed-meshheading:19077293-Receptors, Estrogen,
pubmed-meshheading:19077293-Sequence Analysis, DNA,
pubmed-meshheading:19077293-Sweden
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pubmed:year |
2008
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pubmed:articleTitle |
No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.
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pubmed:affiliation |
Department of Medical and Clinical genetics, Sahlgrenska Academy, Gothenburg, Sweden. annika.bergman@gu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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