Linked Life Data

19076781

Source:http://linkedlifedata.com/resource/pubmed/id/19076781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-16
pubmed:abstractText
A 42-year-old man presented with three months of progressive proximal weakness, a thirty pound weight loss, and dysphagia. He was hospitalized two months earlier for ventilatory failure requiring five days of mechanical ventilation. His history also included long-term hydroxychloroquine therapy for discoid lupus and a recently elevated total creatine kinase. An electromyogram revealed evidence of an irritable myopathy. Microscopic examination of a muscle biopsy specimen revealed vacuolar myopathy with lysosomal activation. Electron microscopy demonstrated curvilinear inclusions that, given his history, were diagnostic of hydroxychloroquine (HCQ) myopathy. Although HCQ myopathy typically presents with proximal muscle weakness and normal-to-mildly-elevated creatine kinase levels, this is one of the few reported cases of ventilatory failure due to HCQ myopathy. Hydroxychloroquine myopathy may be more common than previously reported and should be considered in patients on long term therapy presenting with weakness or ventilatory failure. In these cases, muscle biopsy should be performed to confirm the diagnosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1750-3639
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
42-year-old man with discoid lupus and progressive weakness.
pubmed:publicationType
Letter, Case Reports