Linked Life Data

19076691

Source:http://linkedlifedata.com/resource/pubmed/id/19076691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-12-16
pubmed:abstractText
We used genomic sequencing of Korean subjects to identify the uncoupling protein-1 (UCP1) polymorphism -412A>C (rs3811787 in the dbSNP database). This study is the first to associate this polymorphism with a human phenotype. The frequency of the major A allele was 0.53 and that of the minor C allele was 0.47. The -412A>C polymorphism was not linked to the well-known -3826A>G (rs1800592; mid R:D'mid R:=0.60 and r(2)=0.33), yielding four predicted haplotypes from these two polymorphisms. We associated -412A>C, -3826A>G and their haplotypes with computed tomography-measured body fat areas from 367 Korean female subjects. The G allele of -3826A>G and the C allele of -412A>C were significantly associated with larger areas of abdominal subcutaneous fat in a dominant model (p=0.001 and p=0.0004, respectively); combining them together (ht2[GC]) enhanced this significance (p=0.00005). In contrast, presence of the A allele in both polymorphisms (ht1[AA]) was significantly associated with smaller areas of abdominal subcutaneous fat (p=0.003). We observed no significant associations between these UCP1 genetic polymorphisms and thigh fat areas, visceral fat areas, or blood biochemical profiles, suggesting that this polymorphism might differentially affect fat accumulation in different parts of the human body, even though further study is needed to elucidate the mechanism of it.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1601-5223
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A UCP1-412A>C polymorphism is associated with abdominal fat area in Korean women.
pubmed:affiliation
Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't