rdf:type |
|
lifeskim:mentions |
umls-concept:C0016360,
umls-concept:C0023413,
umls-concept:C0024623,
umls-concept:C0040711,
umls-concept:C0069717,
umls-concept:C0205179,
umls-concept:C0246415,
umls-concept:C0585332,
umls-concept:C0936012,
umls-concept:C1516213,
umls-concept:C1825590,
umls-concept:C2603343,
umls-concept:C2697648
|
pubmed:issue |
3
|
pubmed:dateCreated |
2009-2-27
|
pubmed:abstractText |
Docetaxel-based chemotherapy regimens have demonstrated activity in advanced gastric cancer (AGC). However, a high rate of grade 3/4 hematotoxicity was reported with these regimens. Our purpose was to identify pharmacogenetic markers with potential to detect patients with increased risk to encounter severe hematotoxicity following treatment with 5-fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT).
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1569-8041
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
481-5
|
pubmed:dateRevised |
2009-8-10
|
pubmed:meshHeading |
pubmed-meshheading:19074750-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19074750-Base Sequence,
pubmed-meshheading:19074750-DNA Primers,
pubmed-meshheading:19074750-DNA Repair,
pubmed-meshheading:19074750-Fluorouracil,
pubmed-meshheading:19074750-Humans,
pubmed-meshheading:19074750-Leucovorin,
pubmed-meshheading:19074750-Neutropenia,
pubmed-meshheading:19074750-Organoplatinum Compounds,
pubmed-meshheading:19074750-Pharmacogenetics,
pubmed-meshheading:19074750-Polymerase Chain Reaction,
pubmed-meshheading:19074750-Polymorphism, Genetic,
pubmed-meshheading:19074750-Taxoids
|
pubmed:year |
2009
|
pubmed:articleTitle |
Pharmacogenetic analyses of hematotoxicity in advanced gastric cancer patients receiving biweekly fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
|
pubmed:affiliation |
Department of Internal Medicine I, University Hospital Carl Gustav Carus, University of Dresden, Dresden, Germany.
|
pubmed:publicationType |
Journal Article,
Clinical Trial, Phase II
|