Linked Life Data

19074353

Source:http://linkedlifedata.com/resource/pubmed/id/19074353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5908
pubmed:dateCreated
2008-12-16
pubmed:abstractText
Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
322
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1705-10
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.
pubmed:affiliation
INSERM U653, Institut Curie, 12 rue Lhomond, 75005, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't