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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-29
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pubmed:abstractText |
The presence of heterotrimeric G-proteins at epithelial tight junctions suggests that these cellular junctions are regulated by so far unknown G-protein coupled receptors. We identify here an interaction between the human somatostatin receptor 3 (hSSTR3) and the multiple PDZ protein MUPP1. MUPP1 is a tight junction scaffold protein in epithelial cells, and as a result of the interaction with MUPP1 the hSSTR3 is targeted to tight junctions. Interaction with MUPP1 enables the receptor to regulate transepithelial permeability in a pertussis toxin sensitive manner, suggesting that hSSTR3 can activate G-proteins locally at tight junctions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-3468
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pubmed:author |
pubmed-author:BrandnerJohanna MJM,
pubmed-author:BuckFriedrichF,
pubmed-author:Fernandez-BallesterGregorio JGJ,
pubmed-author:GlassmeierGünterG,
pubmed-author:KreienkampHans-JürgenHJ,
pubmed-author:LiewChong WeeCW,
pubmed-author:RichterDietmarD,
pubmed-author:SchulzStefanS,
pubmed-author:SchwarzJürgen RJR,
pubmed-author:SerranoLuisL,
pubmed-author:VockelMatthiasM
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
583
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-54
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pubmed:meshHeading |
pubmed-meshheading:19071123-Carrier Proteins,
pubmed-meshheading:19071123-Epithelium,
pubmed-meshheading:19071123-GTP-Binding Proteins,
pubmed-meshheading:19071123-Humans,
pubmed-meshheading:19071123-PDZ Domains,
pubmed-meshheading:19071123-Permeability,
pubmed-meshheading:19071123-Pertussis Toxin,
pubmed-meshheading:19071123-Receptors, Somatostatin,
pubmed-meshheading:19071123-Somatostatin,
pubmed-meshheading:19071123-Tight Junctions,
pubmed-meshheading:19071123-Two-Hybrid System Techniques
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pubmed:year |
2009
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pubmed:articleTitle |
Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.
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pubmed:affiliation |
Institut für Zellbiochemie und klinische Neurobiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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