Linked Life Data

19070898

Source:http://linkedlifedata.com/resource/pubmed/id/19070898

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-3-9
pubmed:abstractText
Hypermethylation of several genes with various functions is frequent in myelodysplastic syndromes (MDS), and has led to the use of demethylating agents in clinical trials. The mechanism of hypermethylation remains unclear, limiting the development of new drugs. Hopfer et al. investigated the role of DNA methyltransferases (DNMTs) during in vitro MDS hematopoietic cell differentiation. They found that different subtypes of DNMTs were associated with different lineages in MDS, and also during normal hematopoiesis, suggesting that DNMTs contribute to aberrant methylation in MDS but are not the cause of this phenomenon.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1873-5835
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
601-2
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Methyltransferases in myelodysplastic syndromes: guilty or not guilty?
pubmed:publicationType
Editorial, Comment