Linked Life Data

19070787

Source:http://linkedlifedata.com/resource/pubmed/id/19070787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-12-16
pubmed:abstractText
Metastatic progression consists in multiple, progressive, well structured and organized steps, called the metastatic cascade. These steps are becoming clearer, for example, angiogenesis which is absolutely necessary for tumor growth but also for metastatic colonization in the new organ. There are other concepts such as epithelial mesenchymal transition, the premetastatic niche or the metastatic signature theory. They all participate in an irreversible process which escapes from the host control. Tumor progression is highly dependent on genes that mediate the process but also on important extrinsic phenomena such as the tumor microenvironment (basement membranes, the extracellular matrix). The capacity to colonize one organ and not another could be explained by the "seed and soil" theory which postulates that tumor cells (the seed) will only grow in an.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1166-7087
pubmed:author
pubmed:issnType
Print
pubmed:volume
18 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S156-66
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[The metastatic cascade: angiogenesis and new concepts].
pubmed:affiliation
Service d'Urologie, Université Paris Descartes, France. arnaud.mejean@nck.aphp.fr
pubmed:publicationType
Journal Article, English Abstract