Source:http://linkedlifedata.com/resource/pubmed/id/19070402
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2009-3-27
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pubmed:abstractText |
The gallium(III) complexes [Ga(2Am4DH)(2)]NO(3) (1), [Ga(2Am4Me)(2)]NO(3) (2) and [Ga(2Am4Et)(2)]NO(3) (3) were prepared with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives. The thiosemicarbazones were cytotoxic against malignant RT2 glioblastoma cells (expressing p53 protein) with IC(50) values in the 7.3-360 microM range, and against malignant T98 glioblastoma cells (expressing mutant p53 protein) with IC(50) values in the 3.6-143 microM range. Coordination to gallium strongly increased the cytotoxic potential in complexes 2 and 3, which showed IC(50) values in the 0.81-9.57 microM range against RT2 cells and in the 3.6-11.30 microM range against T98 cells, and were 20-fold more potent than cisplatin. All thiosemicarbazones and gallium complexes were able to induce cell death by apoptosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1768-3254
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1870-7
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pubmed:meshHeading |
pubmed-meshheading:19070402-Antineoplastic Agents,
pubmed-meshheading:19070402-Apoptosis,
pubmed-meshheading:19070402-Cell Line, Tumor,
pubmed-meshheading:19070402-Drug Screening Assays, Antitumor,
pubmed-meshheading:19070402-Gallium,
pubmed-meshheading:19070402-Glioblastoma,
pubmed-meshheading:19070402-Humans,
pubmed-meshheading:19070402-Inhibitory Concentration 50,
pubmed-meshheading:19070402-Structure-Activity Relationship,
pubmed-meshheading:19070402-Thiosemicarbazones
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pubmed:year |
2009
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pubmed:articleTitle |
Gallium(III) complexes of 2-pyridineformamide thiosemicarbazones: cytotoxic activity against malignant glioblastoma.
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pubmed:affiliation |
Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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