Linked Life Data

19065773

Source:http://linkedlifedata.com/resource/pubmed/id/19065773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-12-9
pubmed:abstractText
Caryocar brasiliense Camb. is a tree popularly known in Central Brazil as pequi. Its fruit contains carotenes, retinols, vitamin C, and polyphenols. These compounds possess antioxidant properties preventing excessive free radical formation and modulating the genotoxicity of physical and chemical agents in the body. However, at high concentrations these compounds can have recombinogenic and mutagenic effects, because they can act as pro-oxidants. We examined the genotoxic effects of aqueous extracts of pequi pulp on wing spots of Drosophila melanogaster using the somatic mutation and recombination test (SMART). SMART was applied to a standard cross and to a high bioactivation cross. Two types of descendants were obtained from these crosses: marked-heterozygous (mwh + / + flr3) and balancer-heterozygous (mwh + / + TM3, Bds). Seventy-two-hour larvae from both crosses were treated with pequi pulp extract at 1, 5 and 10%. The extract increased significantly the frequency of mutant spots when compared with the negative control. Recombinogenic effects were also observed in the mwh/TM3 descendants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1676-5680
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1375-83
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Recombinogenic effects of the aqueous extract of pulp from pequi fruit (Caryocar brasiliense) on somatic cells of Drosophila melanogaster.
pubmed:affiliation
Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Uberlândia, MG, Brasil.
pubmed:publicationType
Journal Article