Linked Life Data

19065653

Source:http://linkedlifedata.com/resource/pubmed/id/19065653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-2-3
pubmed:abstractText
Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high-risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person-years over an average of 5.3 years of follow-up. One hundred ten incident cancers were identified. Multiple-primary standardized incidence ratios (MP-SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP-SIR was 1.3 (95% CI: 1.1-1.6), which was largely explained by an excess in NPC (MP-SIR = 15; 95% CI: 10-23). Exclusion of incident NPC diagnoses led to an overall MP-SIR of 1.0 (95% CI: 0.83-1.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP-SIR = 2.0; 95% CI: 1.5-2.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP-SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-10861479, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-11309046, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-12118254, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-12464650, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-15026332, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-15185352, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-16106400, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-16166338, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-1651806, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-17237987, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-2697183, http://linkedlifedata.com/resource/pubmed/commentcorrection/19065653-9274915
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1097-0215
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1622-5
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan.
pubmed:affiliation
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA. yuke@mail.nih.gov
pubmed:publicationType
Journal Article