Linked Life Data

19061871

Source:http://linkedlifedata.com/resource/pubmed/id/19061871

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Cytochrome oxidase (CYO) and acetylcholinesterase (AChE) staining density varies across the cortical layers in many sensory areas. The laminar variations likely reflect differences between the layers in levels of metabolic activity and cholinergic modulation. The question of whether these laminar variations differ between primary sensory cortices has never been systematically addressed in the same set of animals, since most studies of sensory cortex focus on a single sensory modality. Here, we compared the laminar distribution of CYO and AChE activity in the primary auditory, visual, and somatosensory cortices of the mouse, using Nissl-stained sections to define laminar boundaries. Interestingly, for both CYO and AChE, laminar patterns of enzyme activity were similar in the visual and somatosensory cortices, but differed in the auditory cortex. In the visual and somatosensory areas, staining densities for both enzymes were highest in layers III/IV or IV and in lower layer V. In the auditory cortex, CYO activity showed a reliable peak only at the layer III/IV border, while AChE distribution was relatively homogeneous across layers. These results suggest that laminar patterns of metabolic activity and cholinergic influence are similar in the mouse visual and somatosensory cortices, but differ in the auditory cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1872-6240
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
1252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-42
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Mouse auditory cortex differs from visual and somatosensory cortices in the laminar distribution of cytochrome oxidase and acetylcholinesterase.
pubmed:affiliation
UCL Ear Institute, University College London, 332 Gray's Inn Road, London, WC1X 8EE, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't