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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-8-13
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pubmed:abstractText |
We have previously described two cellular immediate-early genes, Egr-1 (mouse) and EGR2 (human) that encode zinc finger proteins. Here we report the characterization of a new member of the Egr family referred to as EGR3 (human). This cDNA clone was isolated using low stringency hybridization with the zinc finger domain of Egr-1. The EGR3 cDNA sequence predicts a 387 amino acid (a.a.) protein containing three Cys2-His2 zinc fingers nearly identical to those of Egr-1 and EGR2. This similarity has a functional consequence: EGR3 can activate transcription of a CAT gene linked to the sequence CGCCCCCGC, a cis element which is a target for Egr-1 and EGR2. We show that EGR3 is an immediate-early growth response gene induced by mitogenic stimulation of rodent and human fibroblasts and a monkey kidney epithelial cell line. The EGR3 gene has a single intron and maps to chromosome 8 at bands p21-23.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
917-28
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1906159-Amino Acid Sequence,
pubmed-meshheading:1906159-Animals,
pubmed-meshheading:1906159-Base Sequence,
pubmed-meshheading:1906159-Cell Line,
pubmed-meshheading:1906159-Chromosome Mapping,
pubmed-meshheading:1906159-DNA,
pubmed-meshheading:1906159-DNA-Binding Proteins,
pubmed-meshheading:1906159-Early Growth Response Protein 1,
pubmed-meshheading:1906159-Early Growth Response Protein 3,
pubmed-meshheading:1906159-Fibroblasts,
pubmed-meshheading:1906159-Genes, Regulator,
pubmed-meshheading:1906159-Haplorhini,
pubmed-meshheading:1906159-Humans,
pubmed-meshheading:1906159-Immediate-Early Proteins,
pubmed-meshheading:1906159-Molecular Sequence Data,
pubmed-meshheading:1906159-Promoter Regions, Genetic,
pubmed-meshheading:1906159-Transcription, Genetic,
pubmed-meshheading:1906159-Transcription Factors,
pubmed-meshheading:1906159-Zinc Fingers
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pubmed:year |
1991
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pubmed:articleTitle |
EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.
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pubmed:affiliation |
Department of Medicine, Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Illinois 60637.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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