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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-1-7
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pubmed:abstractText |
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by synthetic ligands affects the differentiation, proliferation, and apoptosis of cancer cells. However, the controversial nature of current studies and disappointing results from clinical trials raise questions about the contribution of PPARgamma signaling in breast cancer development in the absence of stimulation by exogenous ligands. Recent reports from both in vitro and in vivo studies are inconsistent and suggest that endogenous activation of PPARgamma plays a much more complex role in initiation and progression of cancer than previously thought.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19061500-Apoptosis,
pubmed-meshheading:19061500-Breast Neoplasms,
pubmed-meshheading:19061500-Cell Line, Tumor,
pubmed-meshheading:19061500-Cell Proliferation,
pubmed-meshheading:19061500-Down-Regulation,
pubmed-meshheading:19061500-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19061500-Humans,
pubmed-meshheading:19061500-PPAR gamma,
pubmed-meshheading:19061500-Phenotype,
pubmed-meshheading:19061500-RNA Interference
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pubmed:year |
2008
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pubmed:articleTitle |
Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells.
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pubmed:affiliation |
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536-0298, USA. yyzayt2@email.uky.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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