Linked Life Data

19057314

Source:http://linkedlifedata.com/resource/pubmed/id/19057314

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-12-5
pubmed:abstractText
The pharmacological treatment of cerebral vasospasm (CVS) now includes the experimental use of controlled-release biocompatible compounds that deliver a desired drug locally into the subarachnoid space. A controlled-release system consists of an active material that is incorporated into a carrier, usually in the form of a pellet or a gel. With such systems, the desired agent is delivered slowly and continuously, for long periods of time, directly to the desired site. This technology makes it possible to achieve high local concentrations of therapeutic agents while minimizing systemic toxicity and circumventing the need to cross the blood-brain barrier. This review describes controlled-release systems developed to date for local drug delivery in the treatment of CVS in both animal models and humans.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1524-4040
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1011-9; discussion 1019-21
pubmed:dateRevised
2009-5-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Treatment of cerebral vasospasm with biocompatible controlled-release systems for intracranial drug delivery.
pubmed:affiliation
Department of Neurosurgery, New York Medical College, Valhalla, NY 10595, USA. ibrahim_omeis@nymc.edu
pubmed:publicationType
Journal Article, Meta-Analysis