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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0017262,
umls-concept:C0033713,
umls-concept:C0087140,
umls-concept:C0162542,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0596588,
umls-concept:C1314939,
umls-concept:C1511938,
umls-concept:C1515655,
umls-concept:C2911684
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pubmed:issue |
1
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|
pubmed:dateCreated |
1991-8-2
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|
pubmed:abstractText |
Here we report marked in vivo expression of the c-fos gene in the external soft callus (ESC) and periosteal hard callus (PHC) at the fracture site of adult rat tibia. Northern-blot analysis showed that the ESC expressed a high level of c-fos mRNA from post-fracture day 10 to day 28, the time when endochondral ossification progressed, and that the ossifying PHC also expressed c-fos mRNA. This c-fos expression was followed by sequential expression of the genes for alkaline phosphatase, osteopontin and osteocalcin, which are osteoblastic markers. Immunohistochemical analysis showed that the c-Fos protein was predominantly located in osteoblasts in the ossifying calluses.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
284
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pubmed:geneSymbol |
c-fos
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
42-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1905644-Alkaline Phosphatase,
pubmed-meshheading:1905644-Animals,
pubmed-meshheading:1905644-Blotting, Northern,
pubmed-meshheading:1905644-Cell Differentiation,
pubmed-meshheading:1905644-Female,
pubmed-meshheading:1905644-Fractures, Bone,
pubmed-meshheading:1905644-Gene Expression,
pubmed-meshheading:1905644-Immunohistochemistry,
pubmed-meshheading:1905644-Osteoblasts,
pubmed-meshheading:1905644-Osteocalcin,
pubmed-meshheading:1905644-Osteopontin,
pubmed-meshheading:1905644-Proto-Oncogene Proteins,
pubmed-meshheading:1905644-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:1905644-Proto-Oncogenes,
pubmed-meshheading:1905644-Rats,
pubmed-meshheading:1905644-Rats, Inbred Strains,
pubmed-meshheading:1905644-Sialoglycoproteins,
pubmed-meshheading:1905644-Wound Healing
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pubmed:year |
1991
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pubmed:articleTitle |
Fracture healing induces expression of the proto-oncogene c-fos in vivo. Possible involvement of the Fos protein in osteoblastic differentiation.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Kyoto University Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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