Linked Life Data

19056149

Source:http://linkedlifedata.com/resource/pubmed/id/19056149

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-4-20
pubmed:abstractText
We report the synthesis of collagen related peptides containing the peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys. The anti-thrombotic activity effects of different glycine mutations in this sequence were studied in regard with their different adopted conformations. The biological results could be correlated to the glycine propensity to adopt a more stable polyproline II helix conformation. The incorporation of these sequences in "collagen-like" alpha-triple-helix peptides shows a pro-thrombotic activity compared to a scrambled negative control peptide which possesses no significant activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1768-3254
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2643-50
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Circular dichroism studies of type III collagen mimetic peptides with anti- or pro-aggregant activities on human platelets.
pubmed:affiliation
Laboratoire des Glucides, UMR-CNRS 6219, Faculté de Pharmacie, Université de Picardie Jules Verne, 1 rue des louvels, F-80037 Amiens, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't