|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0031437,
umls-concept:C0038250,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0439659,
umls-concept:C0580822,
umls-concept:C0906368,
umls-concept:C0919458,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594,
umls-concept:C2239176,
umls-concept:C2911684
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-12-5
|
|
pubmed:abstractText |
Hepatocellular carcinoma (HCC) responds poorly to chemotherapy owing to multidrug resistance (MDR). Recent studies showed that part of HCC could be of progenitor cell origin. Because some MDR-conferring transporters [multidrug resistance-associated protein 1 (MRP1), MDR1, MRP3 and breast cancer resistance protein (BCRP)] are expressed in hepatic progenitor cells (HPCs), expression in HCC might reflect a progenitor cell origin and provide the tumour cells with a MDR phenotype.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1478-3231
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1370-80
|
|
pubmed:meshHeading |
pubmed-meshheading:19055643-Carcinoma, Hepatocellular,
pubmed-meshheading:19055643-Cell Line, Tumor,
pubmed-meshheading:19055643-Gene Expression Profiling,
pubmed-meshheading:19055643-Humans,
pubmed-meshheading:19055643-Immunohistochemistry,
pubmed-meshheading:19055643-Microarray Analysis,
pubmed-meshheading:19055643-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:19055643-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19055643-Statistics, Nonparametric,
pubmed-meshheading:19055643-Stem Cells
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin.
|
|
pubmed:affiliation |
Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium. sara.vanderborght@uz.kuleuven.ac.be
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
