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rdf:type |
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lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0042774,
umls-concept:C0220781,
umls-concept:C0220847,
umls-concept:C0243071,
umls-concept:C0441655,
umls-concept:C1699868,
umls-concept:C1707689,
umls-concept:C1880355,
umls-concept:C1883254,
umls-concept:C2607512
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-2
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pubmed:abstractText |
4'-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of several derivatives of 4'-azidocytidine by varying the substituents at the ribose 2' and 3'-positions. The most potent compound in this series is 4'-azidoarabinocytidine with an IC(50) of 0.17 microM in the genotype 1b subgenomic replicon system. The structure-activity relationships within this series of nucleoside analogues are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:BenkestockKurtK,
pubmed-author:CammackNickN,
pubmed-author:HoltLisaL,
pubmed-author:JohanssonNils GunnarNG,
pubmed-author:KalayanovGenadiyG,
pubmed-author:KlumppKlausK,
pubmed-author:Le PogamSophieS,
pubmed-author:LevequeVincentV,
pubmed-author:MaltsevaTatianaT,
pubmed-author:MartinJoseph AJA,
pubmed-author:MorissonVeroniqueV,
pubmed-author:NajeraIsabelI,
pubmed-author:PinhoPedroP,
pubmed-author:RajyaguruSonalS,
pubmed-author:SmithDavid BDB,
pubmed-author:SmithMarkM,
pubmed-author:SundChristianC,
pubmed-author:SwallowStevenS,
pubmed-author:WinqvistAnnaA,
pubmed-author:ZhouXiao-XiongXX
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|
pubmed:issnType |
Electronic
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|
pubmed:day |
8
|
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pubmed:volume |
52
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
219-23
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pubmed:meshHeading |
|
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pubmed:year |
2009
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pubmed:articleTitle |
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
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pubmed:affiliation |
Roche Palo Alto LLC, Palo Alto, California 94304, USA.
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pubmed:publicationType |
Journal Article
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