Linked Life Data

19055399

Source:http://linkedlifedata.com/resource/pubmed/id/19055399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-6-3
pubmed:abstractText
We report the structure of isolated biomolecules, uracil and guanine, demonstrating the capability of a newly developed electron diffraction apparatus augmented with surface-assisted IR laser desorption. This UED-4 apparatus provides a pulsed, dense molecular beam, which is stable for many hours and possibly days. From the diffraction patterns, it is evident that the plume composition is chemically pure, without detectable background from ions, fragmentation products, or molecular aggregates. The vibrational temperature deduced is indeed lower than the translational temperature of the plume indicating that the molecules are intact on such short time scales. The structures of uracil and guanine were refined at the deduced internal temperatures, and we compare the results with those predicted by density functional theory. Such experimental capability opens the door for many other studies of the structure (and dynamics) of biomolecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1520-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2806-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Structure of isolated biomolecules by electron diffraction-laser desorption: uracil and guanine.
pubmed:affiliation
Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't