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pubmed-article:1905534pubmed:abstractTextRat hepatocytes were maintained in a serum-free, hormonally defined medium supplemented with 50-500 microM albumin-bound 20:1 (n-9) vs 20:4 (n-6). The induction of fatty acid synthase mRNA by a mix of insulin/dexamethasone/T3 was inhibited in a dose dependent fashion by 20:4 (n-6). The abundance of beta-actin mRNA was not suppressed by 20:4 (n-6). The expression of fatty acid synthase was actually stimulated 2-fold by 20:1 (n-9). It would appear that the in vivo inhibition of fatty acid synthase gene expression by dietary polyunsaturated fatty acids is a specific hepatocelluar event.lld:pubmed
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pubmed-article:1905534pubmed:articleTitleArachidonic acid suppression of fatty acid synthase gene expression in cultured rat hepatocytes.lld:pubmed
pubmed-article:1905534pubmed:affiliationUnit of Performance Enhancement, Upjohn Company, Kalamazoo, MI 49001.lld:pubmed
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pubmed-article:1905534pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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