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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-7-31
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pubmed:abstractText |
Rat hepatocytes were maintained in a serum-free, hormonally defined medium supplemented with 50-500 microM albumin-bound 20:1 (n-9) vs 20:4 (n-6). The induction of fatty acid synthase mRNA by a mix of insulin/dexamethasone/T3 was inhibited in a dose dependent fashion by 20:4 (n-6). The abundance of beta-actin mRNA was not suppressed by 20:4 (n-6). The expression of fatty acid synthase was actually stimulated 2-fold by 20:1 (n-9). It would appear that the in vivo inhibition of fatty acid synthase gene expression by dietary polyunsaturated fatty acids is a specific hepatocelluar event.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1056-61
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1905534-Animals,
pubmed-meshheading:1905534-Arachidonic Acid,
pubmed-meshheading:1905534-Arachidonic Acids,
pubmed-meshheading:1905534-Blotting, Northern,
pubmed-meshheading:1905534-Cells, Cultured,
pubmed-meshheading:1905534-Dexamethasone,
pubmed-meshheading:1905534-Fatty Acid Synthetase Complex,
pubmed-meshheading:1905534-Fatty Acids, Unsaturated,
pubmed-meshheading:1905534-Gene Expression,
pubmed-meshheading:1905534-Insulin,
pubmed-meshheading:1905534-Kinetics,
pubmed-meshheading:1905534-Liver,
pubmed-meshheading:1905534-Male,
pubmed-meshheading:1905534-RNA, Messenger,
pubmed-meshheading:1905534-Rats,
pubmed-meshheading:1905534-Rats, Inbred Strains,
pubmed-meshheading:1905534-Triiodothyronine
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pubmed:year |
1991
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pubmed:articleTitle |
Arachidonic acid suppression of fatty acid synthase gene expression in cultured rat hepatocytes.
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pubmed:affiliation |
Unit of Performance Enhancement, Upjohn Company, Kalamazoo, MI 49001.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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