Source:http://linkedlifedata.com/resource/pubmed/id/19054677
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-12-24
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pubmed:abstractText |
On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon cancer HT-29 cells, effective anti-corpulence and anticancer compounds were isolated from the peel of Citrus fruits. These bioactive components were identified as polymethoxyflavones and coumarin derivatives by spectroscopic analyses. 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone had the greatest anti-corpulence effects and 3,5,6,7,8,3',5'-heptamethoxyflavone had the greatest anticancer effects. Furthermore, distributions of those bioactive components in the peel of 10 species of Citrus fruits were demonstrated by HPLC analyses.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Obesity Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Coumarins,
http://linkedlifedata.com/resource/pubmed/chemical/Flavones,
http://linkedlifedata.com/resource/pubmed/chemical/coumarin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3391
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-8
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pubmed:meshHeading |
pubmed-meshheading:19054677-3T3-L1 Cells,
pubmed-meshheading:19054677-Adipocytes,
pubmed-meshheading:19054677-Animals,
pubmed-meshheading:19054677-Anti-Obesity Agents,
pubmed-meshheading:19054677-Antineoplastic Agents,
pubmed-meshheading:19054677-Cell Line, Tumor,
pubmed-meshheading:19054677-Citrus,
pubmed-meshheading:19054677-Coumarins,
pubmed-meshheading:19054677-Drug Evaluation, Preclinical,
pubmed-meshheading:19054677-Flavones,
pubmed-meshheading:19054677-Humans,
pubmed-meshheading:19054677-Mice
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pubmed:year |
2009
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pubmed:articleTitle |
Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.
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pubmed:affiliation |
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan. hirata-001@hiroshima-u.ac.jp
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pubmed:publicationType |
Journal Article
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