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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-2-24
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pubmed:abstractText |
Catechol-O-methyltransferase (COMT) is essential for dopamine metabolism in the brain, and normal variation in the COMT Val158Met polymorphism can influence regional brain function during cognitive tasks. How this is affected when central dopamine function is perturbed is unclear. We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-2402
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pubmed:author |
pubmed-author:CollierDavid ADA,
pubmed-author:DemjahaArsimeA,
pubmed-author:DifortiMartaM,
pubmed-author:FuCynthia H YCH,
pubmed-author:HowesOliverO,
pubmed-author:KalidindiSrideviS,
pubmed-author:KaneFergusF,
pubmed-author:KravaritiEugeniaE,
pubmed-author:McDonaldColmC,
pubmed-author:McGuirePhilip KPK,
pubmed-author:MechelliAndreaA,
pubmed-author:MurrayRobin MRM,
pubmed-author:PicchioniMarcoM,
pubmed-author:PrataDiana PDP,
pubmed-author:ToulopoulouTimotheaT
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-80
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pubmed:meshHeading |
pubmed-meshheading:19054502-Adult,
pubmed-meshheading:19054502-Case-Control Studies,
pubmed-meshheading:19054502-Catechol O-Methyltransferase,
pubmed-meshheading:19054502-Cerebral Cortex,
pubmed-meshheading:19054502-Cognition,
pubmed-meshheading:19054502-Female,
pubmed-meshheading:19054502-Genotype,
pubmed-meshheading:19054502-Humans,
pubmed-meshheading:19054502-Language Tests,
pubmed-meshheading:19054502-Male,
pubmed-meshheading:19054502-Neural Pathways,
pubmed-meshheading:19054502-Polymorphism, Single Nucleotide,
pubmed-meshheading:19054502-Schizophrenia,
pubmed-meshheading:19054502-Schizophrenic Psychology
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pubmed:year |
2009
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pubmed:articleTitle |
Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia.
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pubmed:affiliation |
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College, London, United Kingdom. d.prata@iop.kcl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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