Source:http://linkedlifedata.com/resource/pubmed/id/19053747
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
24
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pubmed:dateCreated |
2008-12-18
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pubmed:abstractText |
Aromatic 3,3'-diesters of thiodigalactoside were synthesized in a rapid three-step sequence from commercially available thiodigalactoside and evaluated as inhibitors of cancer- and immunity-related galectins. For each of galectins-1, -3, -7, and -9N-terminal domain, aromatic 3,3'-diesters of thiodigalactoside were found to have affinities in the low micromolar range, which represents a 7-70 fold enhancement over thiodigalactoside itself. No significant improvement was found for galectin-8 N-terminal domain. Two of the compounds were selected for testing in cell culture and were shown to have potent antimigratory effects on human PC-3 prostate and human A549 nonsmall-cell lung cancer cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1520-4804
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8109-14
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pubmed:meshHeading |
pubmed-meshheading:19053747-Cell Line, Tumor,
pubmed-meshheading:19053747-Cell Movement,
pubmed-meshheading:19053747-Drug Design,
pubmed-meshheading:19053747-Drug Screening Assays, Antitumor,
pubmed-meshheading:19053747-Esters,
pubmed-meshheading:19053747-Galectins,
pubmed-meshheading:19053747-Humans,
pubmed-meshheading:19053747-Inhibitory Concentration 50,
pubmed-meshheading:19053747-Kinetics,
pubmed-meshheading:19053747-Lung Neoplasms,
pubmed-meshheading:19053747-Male,
pubmed-meshheading:19053747-Models, Chemical,
pubmed-meshheading:19053747-Prostatic Neoplasms,
pubmed-meshheading:19053747-Protein Structure, Tertiary,
pubmed-meshheading:19053747-Thiogalactosides
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pubmed:year |
2008
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pubmed:articleTitle |
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.
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pubmed:affiliation |
Organic Chemistry, Lund University, POB 124, SE-221 00 Lund, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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