Linked Life Data

19052216

Source:http://linkedlifedata.com/resource/pubmed/id/19052216

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
49
pubmed:dateCreated
2008-12-4
pubmed:abstractText
Cue-induced drug-seeking in rodents progressively increases after withdrawal from operant self-administration of cocaine, heroin, methamphetamine, and alcohol, a phenomenon termed "incubation of drug craving." Here, we used the opiate drug morphine and explored whether incubation of drug craving also occurs in a pavlovian conditioned place preference (CPP) procedure in which rats learn to associate drug effects with a distinct environmental context. We also explored the role of amygdala extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in this incubation. We found that the expression of morphine CPP progressively increases over the first 14 d after the last drug exposure in rats receiving four pairings of low-dose (1 or 3 mg/kg) but not high-dose (10 mg/kg) morphine with a distinct environment. The progressive increase in low-dose (3 mg/kg) morphine CPP was associated with increased ERK phosphorylation (a measure of ERK activity) and CREB (a downstream target of ERK) phosphorylation in central but not basolateral amygdala. Furthermore, inhibition of central but not basolateral amygdala ERK and CREB phosphorylation by U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene] decreased the enhanced (incubated) drug CPP after 14 d of withdrawal from morphine. Finally, stimulation of central amygdala ERK and CREB phosphorylation by NMDA enhanced drug CPP after 1 d of withdrawal from morphine, an effect reversed by U0126. These findings indicate that the rat's response to environmental cues previously paired with morphine progressively increases or incubates over the first 14 d of withdrawal from low but not high morphine doses. Additionally, this "incubation of morphine craving" is mediated by acute activation of central amygdala ERK pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13248-57
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19052216-Amygdala, pubmed-meshheading:19052216-Analgesics, Opioid, pubmed-meshheading:19052216-Animals, pubmed-meshheading:19052216-Butadienes, pubmed-meshheading:19052216-Conditioning (Psychology), pubmed-meshheading:19052216-Cues, pubmed-meshheading:19052216-Cyclic AMP Response Element-Binding Protein, pubmed-meshheading:19052216-Dose-Response Relationship, Drug, pubmed-meshheading:19052216-Environment, pubmed-meshheading:19052216-Enzyme Inhibitors, pubmed-meshheading:19052216-Excitatory Amino Acid Agonists, pubmed-meshheading:19052216-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:19052216-MAP Kinase Signaling System, pubmed-meshheading:19052216-Male, pubmed-meshheading:19052216-Morphine, pubmed-meshheading:19052216-Nitriles, pubmed-meshheading:19052216-Opioid-Related Disorders, pubmed-meshheading:19052216-Phosphorylation, pubmed-meshheading:19052216-Rats, pubmed-meshheading:19052216-Rats, Sprague-Dawley, pubmed-meshheading:19052216-Recurrence, pubmed-meshheading:19052216-Time Factors
pubmed:year
2008
pubmed:articleTitle
Central amygdala extracellular signal-regulated kinase signaling pathway is critical to incubation of opiate craving.
pubmed:affiliation
National Institute on Drug Dependence, Peking University, Beijing 100083, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Intramural