Linked Life Data

19051269

Source:http://linkedlifedata.com/resource/pubmed/id/19051269

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-13
pubmed:abstractText
The neuropeptide-immunoreactive (IR) and neurofilament-IR neurons are two major phenotypical classes in dorsal root ganglion (DRG). Tyrosine kinase receptor (Trk)A, TrkB, and TrkC are three members of the Trk family which may be relevant to neuronal phenotypes. Whether target skeletal muscle cells generate their expression remains unclear. Neurons containing substance P (SP), calcitonin gene-related peptide (CGRP), neurofilament 200 (NF-200), TrkA, TrkB, and TrkC were quantified using immunohistochemistry in rat DRG neuronal cultures and cocultures of DRG neurons and skeletal muscle cells. The percentage of NF-200 and TrkC-expressing neurons in cocultures of DRG neurons and skeletal muscle cells was significantly higher, 26.86% +/- 3.17% (NF-200) and 27.74% +/- 3.63% (TrkC) compared with 20.92% +/- 1.98% (NF-200) and 16.70% +/- 3.68% (TrkC) in DRG cultures; whereas the percentage of SP, CGRP, TrkA, and TrkB-expressing neurons was not changed significantly by the addition of target skeletal muscle cells. Thus, target skeletal muscle cells may influence neurofilament-phenotype and TrkC receptor but not neuropeptide-phenotype and TrkA and TrkB receptors. Anat Rec, 2009. (c) 2008 Wiley-Liss, Inc.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1932-8494
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
292
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-12
pubmed:dateRevised
2009-12-16
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Neuronal phenotype and tyrosine kinase receptor expression in cocultures of dorsal root ganglion and skeletal muscle cells.
pubmed:affiliation
Department of Anatomy, Shandong University School of Medicine, Jinan, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't