Linked Life Data

1904995

Source:http://linkedlifedata.com/resource/pubmed/id/1904995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-7-19
pubmed:abstractText
The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. In both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. The largest increase (2-fold) was observed in striatum for both species. The neuron-specific proteins, synapsin I and neurofilament-200 (Mr 200 kilodaltons), were not altered by aging in any region of the mouse or rat brain. Brains of aged rats, but not mice, showed a decrease in beta-tubulin. The data suggest that astrocytic hypertrophy observed with aging involves an accumulation of glial filaments.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain.
pubmed:affiliation
Neurotoxicology Division (MD-74B), U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.