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rdf:type |
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lifeskim:mentions |
umls-concept:C0002028,
umls-concept:C0004096,
umls-concept:C0026336,
umls-concept:C0591833,
umls-concept:C1045934,
umls-concept:C1260956,
umls-concept:C1280500,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-22
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pubmed:abstractText |
The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness; the detection of TNF-alpha and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L. undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-6351
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pubmed:author |
pubmed-author:AhnChang-BumCB,
pubmed-author:ChoiIl-WhanIW,
pubmed-author:ChoiInhakI,
pubmed-author:HeoSoo-JinSJ,
pubmed-author:JeJae-YoungJY,
pubmed-author:JeonYou-JinYJ,
pubmed-author:JungWon-KyoWK,
pubmed-author:KimJin SooJS,
pubmed-author:KimYoung-MogYM,
pubmed-author:LeeDae-SungDS,
pubmed-author:LeeSoo-WoongSW,
pubmed-author:MoonChisookC,
pubmed-author:OhKwang SooKS,
pubmed-author:OhSangtaekS,
pubmed-author:ParkSae-GwangSG,
pubmed-author:SeoSu-KilSK
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pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19049817-Animals,
pubmed-meshheading:19049817-Anti-Asthmatic Agents,
pubmed-meshheading:19049817-Asthma,
pubmed-meshheading:19049817-Bronchial Hyperreactivity,
pubmed-meshheading:19049817-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19049817-Cytokines,
pubmed-meshheading:19049817-Disease Models, Animal,
pubmed-meshheading:19049817-Female,
pubmed-meshheading:19049817-Flavonoids,
pubmed-meshheading:19049817-Laurencia,
pubmed-meshheading:19049817-Lung,
pubmed-meshheading:19049817-Mice,
pubmed-meshheading:19049817-Mice, Inbred C57BL,
pubmed-meshheading:19049817-Ovalbumin,
pubmed-meshheading:19049817-Phenols,
pubmed-meshheading:19049817-Plant Extracts,
pubmed-meshheading:19049817-Polyphenols
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pubmed:year |
2009
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pubmed:articleTitle |
Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma.
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pubmed:affiliation |
Department of Marine Life Science and Marine Life Research Center, Chosun University, Gwangju 501-759, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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