Linked Life Data

19047733

Source:http://linkedlifedata.com/resource/pubmed/id/19047733

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 12
pubmed:dateCreated
2008-12-2
pubmed:databankReference
pubmed:abstractText
Enterobacter hormaechei is a Gram-negative bacterium within the Enterobacter cloacae complex, and has been shown to be of clinical significance by causing nosocomial infections, including sepsis. Ent. hormaechei is spread via horizontal transfer and is often associated with extended-spectrum beta-lactamase production, which increases the challenges associated with treatment by limiting therapeutic options. This report considers 10 strains of Ent. hormaechei (identified by 16S rDNA sequencing) that had originally been identified by phenotyping as Cronobacter (Enterobacter) sakazakii. Seven strains were from different neonates during a nosocomial outbreak in a California hospital. PFGE analysis revealed a clonal relationship among six of the seven isolates and therefore a previously unrecognized Ent. hormaechei outbreak had occurred over a three-month period. Antibiotic-resistance profiles were determined and extended-spectrum beta-lactamase activity was detected. The association of the organism with powdered infant formula, neonatal hosts and Cr. sakazakii suggested that the virulence of these organisms may be similar. Virulence traits were tested and all strains were shown to invade both gut epithelial (Caco-2) and blood-brain barrier endothelial cells (rBCEC4), and to persist in macrophages (U937). Due to misidentification we suggest that Ent. hormaechei may be an under-reported cause of bacterial infection, especially in neonates. Also, its isolation from various sources, including powdered infant milk formula, makes it a cause for concern and merits further investigation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1350-0872
pubmed:author
pubmed:issnType
Print
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3659-67
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19047733-Animals, pubmed-meshheading:19047733-Bacterial Typing Techniques, pubmed-meshheading:19047733-Caco-2 Cells, pubmed-meshheading:19047733-California, pubmed-meshheading:19047733-Cronobacter sakazakii, pubmed-meshheading:19047733-Cross Infection, pubmed-meshheading:19047733-DNA, Bacterial, pubmed-meshheading:19047733-Diagnostic Errors, pubmed-meshheading:19047733-Disease Outbreaks, pubmed-meshheading:19047733-Drug Resistance, Bacterial, pubmed-meshheading:19047733-Electrophoresis, Gel, Pulsed-Field, pubmed-meshheading:19047733-Endothelial Cells, pubmed-meshheading:19047733-Enterobacter, pubmed-meshheading:19047733-Enterobacteriaceae Infections, pubmed-meshheading:19047733-Humans, pubmed-meshheading:19047733-Infant, Newborn, pubmed-meshheading:19047733-Microbial Sensitivity Tests, pubmed-meshheading:19047733-Molecular Sequence Data, pubmed-meshheading:19047733-Phenotype, pubmed-meshheading:19047733-Rats, pubmed-meshheading:19047733-Sequence Analysis, DNA, pubmed-meshheading:19047733-U937 Cells, pubmed-meshheading:19047733-beta-Lactamases
pubmed:year
2008
pubmed:articleTitle
Characterization of an extended-spectrum beta-lactamase Enterobacter hormaechei nosocomial outbreak, and other Enterobacter hormaechei misidentified as Cronobacter (Enterobacter) sakazakii.
pubmed:affiliation
Nottingham Trent University, School of Science and Technology, Clifton Lane, Nottingham NG11 8NS, UK.
pubmed:publicationType
Journal Article