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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
50
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pubmed:dateCreated |
2008-12-17
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pubmed:abstractText |
The mechanisms by which ethanol damages the developing and adult central nervous system (CNS) remain unclear. Activity-dependent neuroprotective protein (ADNP) is a glial protein that protects the CNS against a wide array of insults and is critical for CNS development. NAPVSIPQ (NAP), a potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential tyrosine phosphorylation of Fyn kinase and the scaffold protein Crk-associated substrate (Cas). Pharmacological inhibition of Fyn kinase or expression of a Fyn kinase siRNA abolished NAP-mediated axon outgrowth. Concentrations of ethanol attained after social drinking blocked NAP-mediated axon outgrowth (IC(50) = 17 mM) by inhibiting NAP activation of Fyn kinase and Cas. These findings identify a mechanism for ADNP regulation of glial-neuronal interactions in developing cerebellum and a pathogenesis of ethanol neurotoxicity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047645-10022583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047645-10037502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047645-11013255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047645-11303069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047645-12235240,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19047645-8651458
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19962-7
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pubmed:dateRevised |
2011-7-13
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pubmed:meshHeading |
pubmed-meshheading:19047645-Animals,
pubmed-meshheading:19047645-Axons,
pubmed-meshheading:19047645-Cell Differentiation,
pubmed-meshheading:19047645-Cells, Cultured,
pubmed-meshheading:19047645-Cerebellum,
pubmed-meshheading:19047645-Crk-Associated Substrate Protein,
pubmed-meshheading:19047645-Ethanol,
pubmed-meshheading:19047645-Gene Knockdown Techniques,
pubmed-meshheading:19047645-Homeodomain Proteins,
pubmed-meshheading:19047645-Nerve Tissue Proteins,
pubmed-meshheading:19047645-Neurons,
pubmed-meshheading:19047645-Phosphorylation,
pubmed-meshheading:19047645-Proto-Oncogene Proteins c-fyn,
pubmed-meshheading:19047645-Rats,
pubmed-meshheading:19047645-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.
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pubmed:affiliation |
VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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