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rdf:type |
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lifeskim:mentions |
umls-concept:C0030956,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0542341,
umls-concept:C0546816,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515655,
umls-concept:C1706438,
umls-concept:C1709305,
umls-concept:C2698600
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pubmed:issue |
23
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pubmed:dateCreated |
2008-12-2
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pubmed:abstractText |
Significant efforts are being devoted toward the development of effective therapeutic vaccines against cancer. Specifically, well-characterized subunit vaccines, which are designed to generate antitumor cytotoxic CD8 T-cell responses. Because CD4 T cells participate at various stages of CD8 T-cell responses, it is important to study the role of CD4 T cells in the induction and persistence of antitumor CD8 T-cell responses by these vaccines. Recent evidence points to the requirement of CD4 T cells for the long-term persistence of memory CD8 T cells, which in the case of cancer immunotherapy would be critical for the prevention of tumor recurrences. The purpose of the present study was to assess whether CD4 T cells are necessary for the generation and maintenance of antigen-specific CD8 T cells induced by subunit (peptide or DNA) vaccines. We have used a vaccination strategy that combines synthetic peptides representing CD8 T-cell epitopes, a costimulatory anti-CD40 antibody and a Toll-like receptor agonist (TriVax) to generate large numbers of antigen-specific CD8 T-cell responses. Our results show that the rate of decline (clonal contraction) of the antigen-specific CD8 T cells and their functional state is not affected by the presence or absence of CD4 T cells throughout the immune response generated by TriVax. We believe that these results bear importance for the design of effective vaccination strategies against cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-11895927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-11936929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-12414983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-12594515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-12690202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-1322235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-14971034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15007094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15240684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15300249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15454922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15662368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15744305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-15922965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-16455988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-16824119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-16920921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-17283170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-17339421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-18056368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-18253731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-18363998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-9346850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-9624003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-9624004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-9624005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19047170-9687535
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Subunit
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1538-7445
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9892-9
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pubmed:dateRevised |
2011-6-7
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pubmed:meshHeading |
pubmed-meshheading:19047170-Animals,
pubmed-meshheading:19047170-Antigens, CD40,
pubmed-meshheading:19047170-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19047170-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19047170-Cancer Vaccines,
pubmed-meshheading:19047170-Epitopes, T-Lymphocyte,
pubmed-meshheading:19047170-Female,
pubmed-meshheading:19047170-Histocompatibility Antigens Class II,
pubmed-meshheading:19047170-Lymphoma, B-Cell,
pubmed-meshheading:19047170-Mammary Neoplasms, Experimental,
pubmed-meshheading:19047170-Melanoma, Experimental,
pubmed-meshheading:19047170-Mice,
pubmed-meshheading:19047170-Mice, Inbred BALB C,
pubmed-meshheading:19047170-Mice, Inbred C57BL,
pubmed-meshheading:19047170-Mice, Knockout,
pubmed-meshheading:19047170-Neoplasms, Experimental,
pubmed-meshheading:19047170-Toll-Like Receptors,
pubmed-meshheading:19047170-Vaccines, DNA,
pubmed-meshheading:19047170-Vaccines, Subunit
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pubmed:year |
2008
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pubmed:articleTitle |
In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.
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pubmed:affiliation |
Department of Immunology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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