Linked Life Data

1904626

Source:http://linkedlifedata.com/resource/pubmed/id/1904626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5012
pubmed:dateCreated
1991-7-12
pubmed:abstractText
The function of the guanosine triphosphate (GTP)-binding protein Ypt1 in regulating vesicular traffic was studied in a cell-free system that reconstitutes transport from the endoplasmic reticulum to the Golgi. Blocking the Ypt1 protein activity resulted in accumulation of vesicles that act as an intermediate passing between the two compartments. The Ypt1 protein was found on the outer side of these vesicles. The transport process is completed by fusion of these vesicles with the acceptor compartment, and Ypt1 protein activity was needed for this step. Thus, a specific GTP-binding protein is required for either attachment or fusion (or both) of secretory vesicles with the acceptor compartment during protein secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1553-6
pubmed:dateRevised
2009-7-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Mediation of the attachment or fusion step in vesicular transport by the GTP-binding Ypt1 protein.
pubmed:affiliation
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't