Source:http://linkedlifedata.com/resource/pubmed/id/19046174
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2008-12-16
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| pubmed:abstractText |
Macrolide resistance among Streptococcus pyogenes (group A streptococci) in Portugal was stable during 1998-2003, but a rapid inversion in the dominant phenotypes was noted in the same period, with a sharp decrease in the proportion of isolates presenting the MLS(B) phenotype and a concomitant increase in isolates presenting the M phenotype. The characterization of group A streptococci recovered during 2004-2006, which is reported here, revealed that resistance was not stable during this period and that the decline in erythromycin resistance observed during 2004-2006 was due to a decrease in the prevalence of isolates presenting the M phenotype, while the proportion of isolates expressing the MLS(B) phenotype remained stable. Characterization by emm typing, T serotyping, pulsed-field gel electrophoresis (PFGE) profiling and multilocus sequence typing revealed a very diverse population. Several of the major PFGE clusters identified had already been found in the 1998-2003 study period, but others were found for the first time, e.g. T11/emm11/ST403, carrying the erm(B) gene, and T3/13/emm3/ST315, carrying the mef(A) gene. The clone defined as T12/emm12/ST36, previously found to be associated with mef(A), was now found to be predominantly associated with erm(B). The clonal dynamics of macrolide-resistant group A streptococci emphasizes the importance of considering factors other than antibiotic consumption in explaining the prevalence of resistant isolates.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Lincosamides,
http://linkedlifedata.com/resource/pubmed/chemical/Macrolides,
http://linkedlifedata.com/resource/pubmed/chemical/Streptogramin B
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1469-0691
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1152-9
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| pubmed:meshHeading |
pubmed-meshheading:19046174-Adult,
pubmed-meshheading:19046174-Anti-Bacterial Agents,
pubmed-meshheading:19046174-Bacterial Typing Techniques,
pubmed-meshheading:19046174-Cluster Analysis,
pubmed-meshheading:19046174-DNA, Bacterial,
pubmed-meshheading:19046174-DNA Fingerprinting,
pubmed-meshheading:19046174-Drug Resistance, Bacterial,
pubmed-meshheading:19046174-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:19046174-Genotype,
pubmed-meshheading:19046174-Humans,
pubmed-meshheading:19046174-Lincosamides,
pubmed-meshheading:19046174-Macrolides,
pubmed-meshheading:19046174-Microbial Sensitivity Tests,
pubmed-meshheading:19046174-Portugal,
pubmed-meshheading:19046174-Sequence Analysis, DNA,
pubmed-meshheading:19046174-Serotyping,
pubmed-meshheading:19046174-Streptococcal Infections,
pubmed-meshheading:19046174-Streptococcus pyogenes,
pubmed-meshheading:19046174-Streptogramin B
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| pubmed:year |
2008
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| pubmed:articleTitle |
Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal.
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| pubmed:affiliation |
Institute of Microbiology/Molecular Medicine, Faculty of Medicine, Lisbon University, Lisbon, Portugal.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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