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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-12-2
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pubmed:abstractText |
HIV type-1 (HIV-1) protease (PR), reverse transcriptase (RT) and integrase (IN) share the same precursor polyprotein and there is much evidence to suggest functional interactions between IN and RT. We aimed to elucidate whether long-term highly active antiretroviral therapy (HAART) targeting PR and RT could influence raltegravir susceptibility and the fitness of IN.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
1359-6535
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
13
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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|
pubmed:pagination |
881-93
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|
pubmed:meshHeading |
pubmed-meshheading:19043922-Amino Acid Substitution,
pubmed-meshheading:19043922-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:19043922-Drug Resistance, Viral,
pubmed-meshheading:19043922-Evolution, Molecular,
pubmed-meshheading:19043922-Genotype,
pubmed-meshheading:19043922-HIV Infections,
pubmed-meshheading:19043922-HIV Integrase,
pubmed-meshheading:19043922-HIV Integrase Inhibitors,
pubmed-meshheading:19043922-HIV-1,
pubmed-meshheading:19043922-Humans,
pubmed-meshheading:19043922-Male,
pubmed-meshheading:19043922-Middle Aged,
pubmed-meshheading:19043922-Phenotype,
pubmed-meshheading:19043922-Pyrrolidinones,
pubmed-meshheading:19043922-Recombination, Genetic,
pubmed-meshheading:19043922-Time Factors,
pubmed-meshheading:19043922-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Raltegravir susceptibility and fitness progression of HIV type-1 integrase in patients on long-term antiretroviral therapy.
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pubmed:affiliation |
IrsiCaixa Foundation, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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