Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-30
pubmed:abstractText
Carcinomas of the Vaterian system are rare and presumably arise from preexisting adenomas (adenoma-carcinoma-sequence). Usually, biopsies are obtained to confirm and specify endoscopic findings, but differentiating reactive atypia from dysplasia or dysplasia from invasive carcinoma can sometimes be difficult or even impossible on morphological criteria alone. In case of invasive carcinoma, furthermore, the precise classification of carcinoma subtypes needs to be established since the distinct subtypes differ significantly in terms of clinical outcome. The cell adhesion proteins CD24, P-cadherin and S100A4 were shown to be expressed in several carcinomas and in dysplastic epithelium but only rarely in normal mucosa. We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater. Although the expression of the cell adhesion proteins did not differ between the carcinoma subtypes, marked differences between normal mucosa, adenoma and carcinoma samples were observed. All marker proteins were expressed in less than 7% of normal mucosa samples (S100A4 in only 1% of cases) and showed an increasing expression from adenoma to invasive carcinoma. Our findings suggest that P-cadherin and S100A4 are helpful in discriminating normal mucosa or reactive atypia from neoplastic lesions. CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1530-0285
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
306-13
pubmed:meshHeading
pubmed-meshheading:19043399-Adenoma, pubmed-meshheading:19043399-Adolescent, pubmed-meshheading:19043399-Adult, pubmed-meshheading:19043399-Aged, pubmed-meshheading:19043399-Aged, 80 and over, pubmed-meshheading:19043399-Ampulla of Vater, pubmed-meshheading:19043399-Antigens, CD24, pubmed-meshheading:19043399-Biopsy, pubmed-meshheading:19043399-Cadherins, pubmed-meshheading:19043399-Carcinoma, pubmed-meshheading:19043399-Common Bile Duct Neoplasms, pubmed-meshheading:19043399-Diagnosis, Differential, pubmed-meshheading:19043399-Europe, pubmed-meshheading:19043399-Female, pubmed-meshheading:19043399-Humans, pubmed-meshheading:19043399-Male, pubmed-meshheading:19043399-Middle Aged, pubmed-meshheading:19043399-Mucous Membrane, pubmed-meshheading:19043399-Neoplasm Invasiveness, pubmed-meshheading:19043399-S100 Proteins, pubmed-meshheading:19043399-Tumor Markers, Biological, pubmed-meshheading:19043399-Young Adult
pubmed:year
2009
pubmed:articleTitle
Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater.
pubmed:affiliation
Institute of Pathology, University of Basel, Basel, Switzerland. dbaumhoer@mac.com
pubmed:publicationType
Journal Article, Multicenter Study