| pubmed-article:19043202 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C0332437 | lld:lifeskim |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C0076552 | lld:lifeskim |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19043202 | lifeskim:mentions | umls-concept:C0066772 | lld:lifeskim |
| pubmed-article:19043202 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19043202 | pubmed:dateCreated | 2008-12-1 | lld:pubmed |
| pubmed-article:19043202 | pubmed:abstractText | The G alpha subunits of the G(12) family of heterotrimeric guanine nucleotide-binding proteins (G proteins), defined by G alpha(12) and G alpha(13), have many cellular functions in common, including stimulation of stress fiber formation and focal adhesion assembly via the small GTPase RhoA activation. We and others previously showed that G alpha(12) and G alpha(13) mediate neurite retraction in neuronal cell lines, but their roles in primary cultured neurons have not been adequately understood. Here, we found that expression of constitutively active mutants of G alpha(12) or G alpha(13) caused growth cone collapse dependent on Rho-kinase activity in hippocampal neurons. The stimulation of thrombin and lysophosphatidic acid (LPA) receptors, which have been thought to selectively couple to G alpha(12) and G alpha(13), respectively, caused growth cone collapse and suppressed axon branching dependent on Rho-kinase activity in hippocampal neurons. Thrombin- and LPA-induced growth cone collapse was suppressed by both single knockdown of G alpha(12) and G alpha(13) with short hairpin RNAs and this suppression was augmented by double knockdown of both G alpha(12) and G alpha(13). These results suggest that thrombin and LPA receptors couple to both G alpha(12) and G alpha(13) for growth cone collapse. | lld:pubmed |
| pubmed-article:19043202 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19043202 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19043202 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19043202 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19043202 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:19043202 | pubmed:author | pubmed-author:NegishiManabu... | lld:pubmed |
| pubmed-article:19043202 | pubmed:author | pubmed-author:KatohHironori... | lld:pubmed |
| pubmed-article:19043202 | pubmed:author | pubmed-author:YamazakiJunya... | lld:pubmed |
| pubmed-article:19043202 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19043202 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:19043202 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19043202 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19043202 | pubmed:pagination | 2216-22 | lld:pubmed |
| pubmed-article:19043202 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:19043202 | pubmed:meshHeading | pubmed-meshheading:19043202... | lld:pubmed |
| pubmed-article:19043202 | pubmed:meshHeading | pubmed-meshheading:19043202... | lld:pubmed |
| pubmed-article:19043202 | pubmed:meshHeading | pubmed-meshheading:19043202... | lld:pubmed |
| pubmed-article:19043202 | pubmed:meshHeading | pubmed-meshheading:19043202... | lld:pubmed |
| pubmed-article:19043202 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19043202 | pubmed:articleTitle | Lysophosphatidic acid and thrombin receptors require both G alpha12 and G alpha13 to regulate axonal morphology in hippocampal neurons. | lld:pubmed |
| pubmed-article:19043202 | pubmed:affiliation | Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:19043202 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19043202 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:81663 | entrezgene:pubmed | pubmed-article:19043202 | lld:entrezgene |
| entrez-gene:303634 | entrezgene:pubmed | pubmed-article:19043202 | lld:entrezgene |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19043202 | lld:entrezgene |
