Linked Life Data

19042038

Source:http://linkedlifedata.com/resource/pubmed/id/19042038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-12
pubmed:abstractText
T-type calcium channels are critically important for regulating neuronal excitability, both in the central and peripheral nervous system, and are essential mediators of hormone secretion. Conversely, T-type channel hyperactivity has been linked to neurological disorders such as absence epilepsy and neuropathic pain. Hence, it is critical to understand the cellular mechanisms that control T-type channel activity, including means of altering expression patterns of the channels, activation of intracellular messenger cascades that directly affect channel activity, and the regulation of alternate splicing of T-type channel genes. Although there is substantial literature dealing with regulation of native T-type channels, the underlying molecular mechanism have only recently been addressed. Here, we highlight recent advances in our understanding of T-type channel regulation, and their implications for brain function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-6147
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-40
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Regulation of neuronal T-type calcium channels.
pubmed:affiliation
Department of Physiology and Biophysics, University of Calgary, Calgary T2N 4N1, Canada.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't