Linked Life Data

19041860

Source:http://linkedlifedata.com/resource/pubmed/id/19041860

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-16
pubmed:abstractText
Biphalin (0.3 mg/kg) administered intravenously (i.v.) to urethane-chloralose anaesthetized rats consistently evoked apnoea, followed by breathing at subnormal respiratory rate with increased tidal volume. Mean arterial pressure and heart rate were lowered. Naloxone completely antagonized the respiratory and cardiovascular responses to biphalin. Midcervical vagotomy prevented all respiratory effects of biphalin, and nearly abolished the fall in blood pressure and attenuated bradycardia. These results indicate that mu opioid receptors distributed in areas supplied by vagal afferents (e.g. the lung) are involved in respiratory and hypotensive effects of biphalin, whereas bradycardia may be explained by activation of brainstem regions mediating cardiovascular control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1879-0712
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
602
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
50-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Respiratory and cardiovascular effects of biphalin in anaesthetized rats.
pubmed:affiliation
Laboratory of Respiratory Reflexes, Polish Academy of Sciences Medical Research Centre, 02-106 Warsaw, 5 Pawi?skiego St., Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't