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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-12-1
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pubmed:abstractText |
Immunoglobulinic (AL) amyloidosis is a complication of plasma cell dyscrasia, characterized by widespread deposition of amyloid fibrils derived from monoclonal light chains. Cardiac amyloid is the main prognostic factor, with a median survival of six months. Cardiac transplantation in AL amyloidosis is associated with high mortality, due to disease recurrence in the allograft and systemic progression. Suppression of light chain (LC) production with chemotherapy by melphalan plus dexamethasone (MD) or high dose melphalan followed by autologous stem cell transplantation (HDM/ASCT) improves survival. However, both the indications and results of chemotherapy in patients transplanted for cardiac AL amyloidosis remain unclear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1875-2136
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pubmed:author |
pubmed-author:BoissonnatPascaleP,
pubmed-author:BridouxFrankF,
pubmed-author:EpaillyEricE,
pubmed-author:GandjbakhchIradjI,
pubmed-author:HerpinDanielD,
pubmed-author:JaccardArnaudA,
pubmed-author:MignotAudeA,
pubmed-author:RedonnetMichelM,
pubmed-author:TouchardGuyG,
pubmed-author:VarnousShaidaS,
pubmed-author:VermesEmmanuelleE
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
523-32
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pubmed:dateRevised |
2011-4-25
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pubmed:meshHeading |
pubmed-meshheading:19041836-Adult,
pubmed-meshheading:19041836-Amyloidosis,
pubmed-meshheading:19041836-Cardiomyopathies,
pubmed-meshheading:19041836-Combined Modality Therapy,
pubmed-meshheading:19041836-Dexamethasone,
pubmed-meshheading:19041836-Female,
pubmed-meshheading:19041836-France,
pubmed-meshheading:19041836-Heart Transplantation,
pubmed-meshheading:19041836-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:19041836-Humans,
pubmed-meshheading:19041836-Male,
pubmed-meshheading:19041836-Melphalan,
pubmed-meshheading:19041836-Middle Aged,
pubmed-meshheading:19041836-Myeloablative Agonists,
pubmed-meshheading:19041836-Recurrence,
pubmed-meshheading:19041836-Retrospective Studies,
pubmed-meshheading:19041836-Stem Cell Transplantation,
pubmed-meshheading:19041836-Time Factors,
pubmed-meshheading:19041836-Transplantation, Autologous,
pubmed-meshheading:19041836-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Heart transplantation in systemic (AL) amyloidosis: a retrospective study of eight French patients.
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pubmed:affiliation |
Department of Cardiology, CHU of Poitiers, University of Poitiers, Poitiers, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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