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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-12-1
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pubmed:abstractText |
Thiazolidinediones (TZDs) are PPARgamma activators that exhibit vasculoprotective properties. To determine the vascular function of PPARgamma, we analyzed Tie2Cre/flox and SM22Cre/flox mice. Unexpectedly, both knockout strains exhibited a significant reduction of circadian variations in blood pressure and heart rate in parallel with diminished variations in urinary norepinephrine/epinephrine excretion and impaired rhythmicity of the canonical clock genes, including Bmal1. PPARgamma expression in the aorta exhibited a robust rhythmicity with a more than 20-fold change during the light/dark cycle. Rosiglitazone treatment induced aortic expression of Bmal1 mRNA, and ChIP and promoter assays revealed that Bmal1 is a direct PPARgamma target gene. These studies have uncovered a role for vascular PPARgamma as a peripheral factor participating in regulation of cardiovascular rhythms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1932-7420
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pubmed:author |
pubmed-author:AoyagiToshinoriT,
pubmed-author:GonzalezFrank JFJ,
pubmed-author:JiaZhanjunZ,
pubmed-author:LitwinSheldon ESE,
pubmed-author:SchnermannJurgen BJB,
pubmed-author:SoodvilaiSunhapasS,
pubmed-author:SymonsJ DavidJD,
pubmed-author:WangNingningN,
pubmed-author:YangGuangruiG,
pubmed-author:YangTianxinT,
pubmed-author:ZhangHuiH
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
482-91
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19041764-ARNTL Transcription Factors,
pubmed-meshheading:19041764-Animals,
pubmed-meshheading:19041764-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:19041764-Biological Clocks,
pubmed-meshheading:19041764-Blood Pressure,
pubmed-meshheading:19041764-Cells, Cultured,
pubmed-meshheading:19041764-Circadian Rhythm,
pubmed-meshheading:19041764-Darkness,
pubmed-meshheading:19041764-Eating,
pubmed-meshheading:19041764-Heart Rate,
pubmed-meshheading:19041764-Hypoglycemic Agents,
pubmed-meshheading:19041764-Mice,
pubmed-meshheading:19041764-Mice, Knockout,
pubmed-meshheading:19041764-Mutation,
pubmed-meshheading:19041764-PPAR gamma,
pubmed-meshheading:19041764-Promoter Regions, Genetic,
pubmed-meshheading:19041764-RNA, Messenger,
pubmed-meshheading:19041764-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19041764-Thiazolidinediones
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pubmed:year |
2008
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pubmed:articleTitle |
Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.
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pubmed:affiliation |
Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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