Source:http://linkedlifedata.com/resource/pubmed/id/19041064
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2008-12-1
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pubmed:abstractText |
Microvessel injury is associated with the development of graft-versus-host disease (GVHD), whereas high levels of posttransplantation vascular endothelial growth factor (VEGF) have a protective effect on severe acute GVHD (aGVHD) and transplantation-related mortality. The current study aimed to determine the impact of VEGFA gene single-nucleotide polymorphisms (SNPs) on the risk of aGVHD after allogeneic stem cell transplantation (SCT). Using polymerase chain reaction and restriction fragment length polymorphism, 4 VEGFA SNPs- -2578 C>A (rs699947), -460 T>C (rs833061), +405 G>C (rs2010963), and +936 C>T (rs3025039)-were analyzed in 98 recipients. Strong linkage disequilibrium was noted among loci -2578, -460, and +405, but not among these loci and locus +936. Accordingly, 4 haplotypes were generated based on the genotypes of -2578, -460, and +405: CTC (47.9%), CTG (26.7%), ACG (24.2%), and CCC (1.0%). The group with low VEGF production (ie, +936CT genotype and 2 copies of the ACG haplotype) had a higher incidence of aGVHD. Significant associations were found between the risk of grade 2-4 aGVHD and the +936 CT (P = .006), -2578 AA (P = .003), and -460 CC (P = .002) genotypes and the ACG haplotype (P = .003). No association between the VEGFA SNPs and chronic GVHD was observed. The VEGFA SNPs might predict a lower risk of aGVHD. Our findings suggest that VEGF may have a protective role in the pathogenesis of aGVHD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1523-6536
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1408-16
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pubmed:meshHeading |
pubmed-meshheading:19041064-Adolescent,
pubmed-meshheading:19041064-Adult,
pubmed-meshheading:19041064-Female,
pubmed-meshheading:19041064-Graft vs Host Disease,
pubmed-meshheading:19041064-Haplotypes,
pubmed-meshheading:19041064-Humans,
pubmed-meshheading:19041064-Incidence,
pubmed-meshheading:19041064-Linkage Disequilibrium,
pubmed-meshheading:19041064-Male,
pubmed-meshheading:19041064-Middle Aged,
pubmed-meshheading:19041064-Neoplasms,
pubmed-meshheading:19041064-Polymorphism, Single Nucleotide,
pubmed-meshheading:19041064-Predictive Value of Tests,
pubmed-meshheading:19041064-Risk Factors,
pubmed-meshheading:19041064-Stem Cell Transplantation,
pubmed-meshheading:19041064-Transplantation, Homologous,
pubmed-meshheading:19041064-Vascular Endothelial Growth Factor A
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pubmed:year |
2008
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pubmed:articleTitle |
Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.
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pubmed:affiliation |
Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea. drkiim@medimail.co.kr
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pubmed:publicationType |
Journal Article
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