Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-28
pubmed:abstractText
Phosphorylation of the p65 subunit of NF-kappaB is required for its transcriptional activity. Recent reports show that phosphorylation of p65 at serine 276 regulates only a subset of genes, such as those encoding IL-6, IL-8, Gro-beta, and ICAM-1. In order to identify additional genes regulated by serine 276 phosphorylation, HepG2 hepatoma cells were infected with adenoviruses encoding either wild-type p65 or the S276A mutant of p65, followed by DNA microarray analysis. The results show that mutation of serine 276 affected the expression of several genes that encode proteins involved in cell cycle regulation, signal transduction, transcription, and metabolism. Notably, expression of S276A increased the mRNA and protein level of p27, a cell cycle inhibitory protein, which led to an increased association of p27 with cdk2, and inhibition of cdk2 activity. Furthermore, while wild-type NF-kappaB is known to increase cell proliferation in a number of different cancer cell lines, our data shows that S276A inhibited cell proliferation. Evidence is mounting that NF-kappaB plays a pivotal role in oncogenesis. Therapeutic agents that regulate the phosphorylation of serine 276 and p27 gene expression, therefore, may be useful as anti-cancer agents in the future.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10385618, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10385644, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10397455, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10454583, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10521409, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10542243, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10593907, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10913132, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10938077, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-10956409, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-11147598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-11819787, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12403783, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12417722, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12419817, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12559944, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12628924, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12842894, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-12881425, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-14720322, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15133847, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15161709, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15192014, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15329734, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15465828, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15516339, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-15585582, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-18362169, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-7758941, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-8011280, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-8717528, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-9096323, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-9482916, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-9660950, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-9792644, http://linkedlifedata.com/resource/pubmed/commentcorrection/19038492-9988711
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1872-7980
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
275
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-49
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
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