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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-3-30
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pubmed:abstractText |
Patients with delusional depression are difficult to treat. The atypical antidepressant trimipramine was effective in a previous 4-week open label pilot study in patients with this disorder. The major neurobiological effect of trimipramine is the inhibition of the hypothalamic-pituitary-adrenocortical (HPA) system. In delusional depression HPA overactivity is more distinct than in other subtypes of depression. HPA suppression is thought to contribute to the action of trimipramine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1879-1379
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pubmed:author |
pubmed-author:AcklNibalN,
pubmed-author:HatzingerMartinM,
pubmed-author:HeldKatjaK,
pubmed-author:Holsboer-TrachslerEdithE,
pubmed-author:HolsboerFlorianF,
pubmed-author:IsingMarcusM,
pubmed-author:KünzelHeike EHE,
pubmed-author:KaschkaWolfgangW,
pubmed-author:KasperSiegfriedS,
pubmed-author:KonstantinidisAnastasiosA,
pubmed-author:SonntagAnnetteA,
pubmed-author:SteigerAxelA,
pubmed-author:UhrManfredM,
pubmed-author:YassouridisAlexanderA
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
702-10
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pubmed:meshHeading |
pubmed-meshheading:19038406-Adrenocorticotropic Hormone,
pubmed-meshheading:19038406-Adult,
pubmed-meshheading:19038406-Amitriptyline,
pubmed-meshheading:19038406-Anti-Dyskinesia Agents,
pubmed-meshheading:19038406-Antidepressive Agents, Tricyclic,
pubmed-meshheading:19038406-Corticotropin-Releasing Hormone,
pubmed-meshheading:19038406-Delusions,
pubmed-meshheading:19038406-Depressive Disorder,
pubmed-meshheading:19038406-Dexamethasone,
pubmed-meshheading:19038406-Dose-Response Relationship, Drug,
pubmed-meshheading:19038406-Double-Blind Method,
pubmed-meshheading:19038406-Drug Therapy, Combination,
pubmed-meshheading:19038406-Electrocardiography,
pubmed-meshheading:19038406-Electroencephalography,
pubmed-meshheading:19038406-Female,
pubmed-meshheading:19038406-Haloperidol,
pubmed-meshheading:19038406-Humans,
pubmed-meshheading:19038406-Hydrocortisone,
pubmed-meshheading:19038406-Hypothalamo-Hypophyseal System,
pubmed-meshheading:19038406-Male,
pubmed-meshheading:19038406-Middle Aged,
pubmed-meshheading:19038406-Pituitary-Adrenal System,
pubmed-meshheading:19038406-Psychiatric Status Rating Scales,
pubmed-meshheading:19038406-Psychomotor Agitation,
pubmed-meshheading:19038406-Treatment Outcome,
pubmed-meshheading:19038406-Trimipramine
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pubmed:year |
2009
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pubmed:articleTitle |
Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial.
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pubmed:affiliation |
Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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