Linked Life Data

19038326

Source:http://linkedlifedata.com/resource/pubmed/id/19038326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-2-9
pubmed:abstractText
In humans, atopic dermatitis (AD) is believed to result from a complex interaction between genetic and environmental factors. Based on recent evidence, it has been proposed that neurotrophins play an important role in allergic inflammation. Levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in blood have been found to be elevated and correlated positively with disease in AD patients. Therefore, we sought to evaluate the role of nucleotide variation in the NGFB and BDNF genes in relation to the pathogenesis of AD. A functional polymorphism within the BDNF gene (Val66Met) and six selected polymorphisms in the NGFB gene were examined in 361 German AD patients and 325 non-atopic controls. In this cohort, no significant association with AD was detected, refuting the hypothesis that variation in these two neurotrophin genes contributes substantially to AD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0890-8508
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Variation in the BDNF and NGFB genes in German atopic dermatitis patients.
pubmed:affiliation
Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany. sabine.hoffjan@rub.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't