|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
48
|
|
pubmed:dateCreated |
2008-11-27
|
|
pubmed:abstractText |
Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2-5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expressed by neurons in the CNS. Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-11536053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-11553913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-11711859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-12202822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-12901789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-1483388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-15139018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-15504915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-15634790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-15741237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-15893517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-16311015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-17558405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-17724116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-17724124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-17823505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-17967169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-18003830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-7512949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-9396006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19036974-9545178
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1529-2401
|
|
pubmed:author |
pubmed-author:ChenTaoT,
pubmed-author:FEIL MLM,
pubmed-author:GaoJingJ,
pubmed-author:HuXuemeiX,
pubmed-author:LiHongH,
pubmed-author:ParkJinsilJ,
pubmed-author:PengXiaozhongX,
pubmed-author:QiangBoqinB,
pubmed-author:QiuMengshengM,
pubmed-author:YuanJiangangJ,
pubmed-author:ZhuQiangQ,
pubmed-author:ZhuYingY
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
26
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
12815-9
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:19036974-Animals,
pubmed-meshheading:19036974-Axons,
pubmed-meshheading:19036974-Cell Adhesion,
pubmed-meshheading:19036974-Cell Adhesion Molecules,
pubmed-meshheading:19036974-Cell Communication,
pubmed-meshheading:19036974-Central Nervous System,
pubmed-meshheading:19036974-Gene Expression Regulation, Developmental,
pubmed-meshheading:19036974-Gene Targeting,
pubmed-meshheading:19036974-Genes, Reporter,
pubmed-meshheading:19036974-Immunoglobulins,
pubmed-meshheading:19036974-Membrane Proteins,
pubmed-meshheading:19036974-Mice,
pubmed-meshheading:19036974-Mice, Inbred C57BL,
pubmed-meshheading:19036974-Mice, Knockout,
pubmed-meshheading:19036974-Mice, Transgenic,
pubmed-meshheading:19036974-Microscopy, Electron, Transmission,
pubmed-meshheading:19036974-Nerve Fibers, Myelinated,
pubmed-meshheading:19036974-Neural Cell Adhesion Molecules,
pubmed-meshheading:19036974-Neurogenesis,
pubmed-meshheading:19036974-Oligodendroglia,
pubmed-meshheading:19036974-Optic Nerve,
pubmed-meshheading:19036974-Spinal Cord,
pubmed-meshheading:19036974-Time Factors,
pubmed-meshheading:19036974-Transplantation Chimera
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS.
|
|
pubmed:affiliation |
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
