Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-12-9
pubmed:abstractText
To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. A close analog was evaluated in preclinical in vivo models of rheumatoid arthritis (RA).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0004-3591
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3765-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19035474-Administration, Oral, pubmed-meshheading:19035474-Animals, pubmed-meshheading:19035474-Anti-Inflammatory Agents, pubmed-meshheading:19035474-Arthritis, Rheumatoid, pubmed-meshheading:19035474-Benzamides, pubmed-meshheading:19035474-Cytokines, pubmed-meshheading:19035474-Disease Models, Animal, pubmed-meshheading:19035474-Down-Regulation, pubmed-meshheading:19035474-Female, pubmed-meshheading:19035474-Fibroblasts, pubmed-meshheading:19035474-HSP72 Heat-Shock Proteins, pubmed-meshheading:19035474-HSP90 Heat-Shock Proteins, pubmed-meshheading:19035474-Humans, pubmed-meshheading:19035474-Jurkat Cells, pubmed-meshheading:19035474-Macrophages, pubmed-meshheading:19035474-Male, pubmed-meshheading:19035474-Mice, pubmed-meshheading:19035474-Mitogen-Activated Protein Kinases, pubmed-meshheading:19035474-NF-kappa B, pubmed-meshheading:19035474-NIH 3T3 Cells, pubmed-meshheading:19035474-Neovascularization, Physiologic, pubmed-meshheading:19035474-Nitric Oxide, pubmed-meshheading:19035474-Rats, pubmed-meshheading:19035474-Rats, Inbred Lew, pubmed-meshheading:19035474-Rats, Sprague-Dawley, pubmed-meshheading:19035474-Signal Transduction, pubmed-meshheading:19035474-Synovial Membrane, pubmed-meshheading:19035474-omega-Conotoxins
pubmed:year
2008
pubmed:articleTitle
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
pubmed:affiliation
Serenex Inc., Durham, North Carolina 27701, USA.
pubmed:publicationType
Journal Article