Linked Life Data

19034702

Source:http://linkedlifedata.com/resource/pubmed/id/19034702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-12-24
pubmed:abstractText
The Wnt signaling pathway has been implicated in the genesis of numerous human cancers. A member of the Wnt family of genes, Wnt4, has been known to regulate proliferation of anterior pituitary cell types in the mouse during embryonic development. In order to elucidate the roles of Wnt signaling in human pituitary adenomas, we examined the expression of Wnt4 and its putative receptor Frizzled6 (Fzd6) by immunohistochemistry in pituitary adenomas and normal pituitaries. Expression of Wnt4 was higher in growth hormone-producing adenomas (GHomas), prolactin-producing adenomas (PRLomas), and thyroid-stimulating hormone-producing adenomas (TSHomas) than in the normal pituitary. Fzd6 was widely expressed in GHomas, PRLomas, TSHomas, and gonadotropin subunit (GnSU)-positive adenomas. In normal pituitary glands, Wnt4 and Fzd6 were colocalized predominantly in follicle-stimulating hormone-, luteinizing hormone-, and alpha-subunits of glycoprotein hormone-positive cells. The canonical Wnt/beta-catenin signaling pathway was analyzed by beta-catenin immunohistochemistry. beta-Catenin was localized at the cell membrane in all pituitary adenomas, but not in the nuclei. On the other hand, Erk1/2 was highly activated in GHomas and TSHomas. These results suggested that activation of Wnt4/Fzd6 signaling through a "beta-catenin-independent" pathway played a role in proliferation and survival of the pituitary adenoma cells. Detailed involvement of transcription factors including Pit-1 remains to be further investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1046-3976
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-73
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19034702-Adenoma, pubmed-meshheading:19034702-Adolescent, pubmed-meshheading:19034702-Adult, pubmed-meshheading:19034702-Aged, pubmed-meshheading:19034702-Female, pubmed-meshheading:19034702-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:19034702-Frizzled Receptors, pubmed-meshheading:19034702-Gene Expression Profiling, pubmed-meshheading:19034702-Gene Expression Regulation, Neoplastic, pubmed-meshheading:19034702-Humans, pubmed-meshheading:19034702-Immunoenzyme Techniques, pubmed-meshheading:19034702-Male, pubmed-meshheading:19034702-Middle Aged, pubmed-meshheading:19034702-Pituitary Gland, pubmed-meshheading:19034702-Pituitary Neoplasms, pubmed-meshheading:19034702-Receptors, G-Protein-Coupled, pubmed-meshheading:19034702-Signal Transduction, pubmed-meshheading:19034702-Tumor Markers, Biological, pubmed-meshheading:19034702-Wnt Proteins, pubmed-meshheading:19034702-Wnt4 Protein, pubmed-meshheading:19034702-Young Adult, pubmed-meshheading:19034702-beta Catenin
pubmed:year
2008
pubmed:articleTitle
Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway.
pubmed:affiliation
Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't